期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 90, 期 -, 页码 523-530出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.05.009
关键词
Biomaterials; Surface topography; Cell adhesion; Cell survival
资金
- National Natural Science Foundation of China [51671140, 31400815]
- Natural Science Foundation of Shanxi Province [2015021063]
- Qualified Personnel Foundation of Taiyuan University of Technology (QPFT) [tyutrc-2011257a]
- Shanxi Scholarship Council of China [2015-034]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 11301215]
- City University of Hong Kong Applied Research Grant (ARG) [9667144]
The surface topography of biomaterials is known to influence cellular response such as adhesion, spreading and differentiation. In this work, the behavior of osteoblasts and endothelial cells on nano-structured Zr and micro/nano-structured ZrO2 alloyed layers of Ti-6Al-4V (TC4) was investigated. Zr alloyed layer (Zr@TC4) decreases the hydrophilicity whereas ZrO2 alloyed layers (ZrO2@TC4) is more hydrophilic than TC4 and more proteins adsorb on ZrO2@TC4 followed by Zr@TC4. The cells proliferate steadily on the smooth TC4 and nano-structured Zr@TC4 surfaces and the osteoblast activity is more pronounced on Zr@TC4 than TC4. The micro/nano-structured surface on ZrO2@TC4 restricts cellular adhesion and spreading independent of the surface wettability and protein adsorption. The findings provide insights into the design of micro/nano-structured biomaterials and interfaces with controlled tissue response.
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