期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 90, 期 -, 页码 379-386出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.04.066
关键词
Mussel-inspired coating; Maxillary bone implant; Anti-bacterial; Nano-silver; Osteogenic hydrogel
资金
- National Natural Science Foundation of China [U1601221, 31572343]
- Guangdong Province Science and Technology Projects [2016B090913004]
- NSERC
Infection compromises healing process after bone fracture. An anti-bacterial bone graft synthesized from polymer and mineralization components is becoming preferable for its accessibility and low cost and tunable chem-physic properties. In this study, mussel-inspired polydopamine (PDA) was used to synthesize in-situ silver nanoparticles (AgNPs) and mineralization on polyethylene hydrogel (PEG). With dual functions of anti-bacteria and graft mineralization, we found the hydrogel (AgNPs/PDA) promoted bone generation and show significant antibacterial activity. Specifically, the gel upregulated the expression of osteogenic genes of bone sialoprotein gene, alkaline phosphatase, osteocalcin and runt-related transcription factor 2. It also significantly inhibited the growth of Staphylococcus aureus and Escherichia coli. In vivo the AgNPs/PDA gel could repair maxillary bone defect efficiently.
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