期刊
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
卷 21, 期 2, 页码 -出版社
UNIV FED SAO CARLOS, DEPT ENGENHARIA MATERIALS
DOI: 10.1590/1980-5373-MR-2017-0488
关键词
emulsion; menthol; micro/nanospheres; PLGA
资金
- Hewlett-Packard Brasil Ltda
- FINEP
- PRONEX/FAPERGS
- CNPq
Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nano spheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 mu m and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.
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