期刊
MATERIALS LETTERS
卷 215, 期 -, 页码 87-90出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2017.12.075
关键词
Biomaterials; Sol-gel preparation; Bioactive glasses; Transition metals; Human fibroblasts; Human umbilical vein endothelial cells
资金
- Polish Ministry of Science and Higher Education [15.11.160.014]
- National Science Centre, Poland [2014/13/B/ST8/02973, 2017/24/T/ST8/00041]
The copper and cobalt-doped bioactive glasses (BGs) from the basic SiO2-CaO-P2O5 system, differing in the CaO/SiO2 molar ratios, were produced using sol-gel method. The in vitro angiogenic response of human fibroblasts and umbilical vein endothelial cells (HUVECs) on Cu-BGs and Co-BGs was investigated. The incorporation of Cu and Co into BGs significantly enhanced vascular endothelial growth factor secretion from fibroblasts. Cu-BGs and Co-BGs extracts might facilitate the migration of HUVECs and the self-assembled network formation after 3 days of culture without basement membrane matrix, demonstrating strong angiogenic activity. The results show that cellular response was correlated with Cu and Co release rate which, in turn, was affected by the CaO/SiO2 molar ratios, indicating new opportunities for controlling the release rate of therapeutic ions from BGs. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据