期刊
MARINE DRUGS
卷 16, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md16070229
关键词
marine-derived fungus; Dichotomomyces cejpii; polyketides; alkaloids; antiviral activity; dengue virus
资金
- Guangdong Provincial Science and Technology Research Program [2014A020217004, 2015A020216007, 2016A020222004]
- National Science and Technology Major Project for New Drug Innovation and Development [2017ZX09305010]
- Fundamental Research Funds for the Central Universities [15ykpy05]
- Mahidol University the Thailand Research Fund [BRG6080006]
- Mahidol University
In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of L-tryptophan and L-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.
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