期刊
MARINE DRUGS
卷 16, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md16070226
关键词
marine fungus; Trichoderma saturnisporum; saturnispols A-H; structural elucidation; antibacterial effects
资金
- 973 program [2015CB755906]
- National Natural Science Foundation of China [21672010, 81630089, 41376127, U1606403]
- TUBITAK [BMBF114S916]
Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A-H (1-8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 mu g/mL, while saturnispol H showed selective effects against VRE and B. subtilis.
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