期刊
MARINE DRUGS
卷 16, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/md16020045
关键词
mangrove endophyte; Aspergillus sp; marine natural product; asperphenone; antibacterial activity
资金
- National Natural Science Fund of China [81673333, 81522042, 21572100, 81421091, 81500059, 41406083, 21672101, 21661140001]
- Jiangsu Provincial Key Medical Discipline (laboratory) [SBK2015022152, ZDXKA2016020]
Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A-C (1-3), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, Aspergillus sp. YHZ-1. The chemical structures of these natural products were elucidated on the basis of mass spectrometry, one- and two-dimensional NMR spectroscopic analysis and asperphenone A and B were confirmed by single-crystal X-ray crystallography. Compounds 1 and 2 exhibited weak antibacterial activity against four Gram-positive bacteria, Staphylococcus aureus CMCC(B) 26003, Streptococcus pyogenes ATCC19615, Bacillus subtilis CICC 10283 and Micrococcus luteus, with the MIC values higher than 32.0 mu M.
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