期刊
MARINE DRUGS
卷 16, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md16060187
关键词
Aequorivita; Gram-negative bacterium; miniaturized culture chip; linear aminolipid; MRSA; LC-MS/MS
资金
- German Academic Exchange Service (DAAD)
The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (1-3) and four known (4-7) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [alpha](D) and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22-145 mu g/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita.
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