期刊
MARINE DRUGS
卷 16, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/md16040114
关键词
algal-derived endophytic fungus; Aspergillus alabamensis; diketomorpholine; steroid; antimicrobial activity
资金
- Natural Science Foundation of China (NSFC) [31330009]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Taishan Scholar Project from Shandong Province of China
Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12 beta,15 alpha,25-trihydroxyergosta-4,6,8(14), 22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (4-7). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 1-7 were evaluated.
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