期刊
MARINE DRUGS
卷 16, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/md16040103
关键词
Sinularia polydactyla; diterpenoids; PTP1B inhibitory activity
资金
- Natural Science Foundation of China [81520108028, 21672230]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- SKLDR/SIMM Project [SIMM1705ZZ-01]
- Syngenta-SIMM-PhD Studentship Project
A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (4-7 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.
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