期刊
MARINE DRUGS
卷 16, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md16010006
关键词
marine natural products; purines; methylpurines; alkylpurines; terpenylpurines; cytotoxicity; antimicrobial activity
资金
- Spanish Ministerio de Economia y Competitividad (MINECO) [CTQ 2015-68175-R, AGL2016-79813-C2-2-R]
- Junta de Castilla y Leon
- Fondo Social Europeo (FSE) of the European Union
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure-activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields.
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