期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 56, 期 10, 页码 993-1005出版社
WILEY
DOI: 10.1002/mrc.4704
关键词
homodecoupling; HSQC; NMR; pure shift; real time
资金
- Engineering and Physical Sciences Research Council [EP/N033949]
- EPSRC [EP/N033949/1] Funding Source: UKRI
Pure shift NMR spectroscopy has become an efficient tool for improving resolution in proton NMR spectra by removing the effect of homonuclear couplings. The introduction of real-time acquisition methods has allowed the main drawback of pure shift NMR, the long experiment times needed, to be circumvented. Real-time methods use periodic application of J-refocusing pulse sequence elements, acquiring a single free induction decay, in contrast to previous methods that construct a pure shift interferogram by concatenating excerpts from multiple free induction decays. In the important heteronuclear single-quantum correlation experiment, implementing real-time pure shift data acquisition typically leads to the simultaneous improvement of both resolution and sensitivity. The current limitations of and problems with real-time pure shift acquisition methods are discussed here in the context of heteronuclear single-quantum correlation experiments. We aim to provide a detailed account of the technical challenges, together with a practical guide to exploiting the full potential of such methods.
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