期刊
MACROMOLECULES
卷 51, 期 7, 页码 2682-2689出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.8b00383
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资金
- Australian Research Council (ARC)
- Fonds der Chemischen Industrie (FCI)
- Karlsruhe Institute of Technology (KIT)
- Science and Technology of Nanosystems (STN) programs
- Queensland University of Technology (QUT)
We introduce a powerful variant of the copper(I)-mediated azide-alkyne cycloaddition (CuAAC) for the synthesis of miktoarm block copolymers with a fluorescently labeled core. Via the simple addition of a functional azirine to a conventional CuAAC reaction of an azide and alkyne terminal polymer strand, a vinyl functionality is introduced at the focal point of the two polymers, which can subsequently be modified, via, e.g., radical thiol-ene addition. Concomitantly, a second functionality a pyrene chromophore stemming from the functional azirine is introduced enabling fluorescence detection and unimolecular micelle formation. Thus, by virtue of thiol terminal polymers an efficient two-step synthesis of midchain functional mikto-three armed star polymers is possible. Detailed NMR, SEC, DSC, UV-vis, and fluorescence studies underpin the successful formation of the functional miktoarm star with a fluorescence labeled core. Finally, yet importantly, dynamic light scattering (DLS) results demonstrate that the miktoarm polymers form self-fluorescent micelles in aqueous media and display robust micellar stability with unimolecular micellar characteristics.
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