期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 39, 期 20, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201800062
关键词
antibacterials; bone regeneration; dual-purpose; microspheres
资金
- National Key R&D Program of China [2017YFC1104300/4302]
- National Natural Science Foundation of China [51473016]
- Beijing Municipal Natural Science Foundation [7182068]
Bone defect repair, especially in terms of infection, remains a big challenge in clinical therapy. To meet clinical requirements, the dual-functional strategy including antibacterial activity and strong osteogenesis effect is a promising approach in bone tissue engineering. In the present study, bioresorbable porous-structured microspheres are fabricated from amphiphilic block copolymer composed of poly(l-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres are loaded with nanosilver via reduction of silver nitrate and apatite via biomineralization in sequence. The resulting composite microspheres are systematically characterized by in vitro coculturing with rat bone mesenchymal stromal cells and Staphylococcus aureus to evaluate cytotoxicity and antibacterial activity. In vivo evaluation is carried out by filling the composite microspheres into infected cranial defects in a rat model. The primary results indicate that the dual-purpose microspheres have the capacity to defeat infection while promoting bone regeneration.
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