期刊
MACROMOLECULAR MATERIALS AND ENGINEERING
卷 303, 期 5, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201700666
关键词
bead-on-string; biofibers; colon cancer; localized chemotherapy; silk fibroin
资金
- Fundamental Research Funds for the Central Universities [XDJK2017B058]
- Chongqing Postdoctoral Science Special Foundation [Xm2016032]
- State Key Laboratory of Silkworm Genome Biology
- National Natural Science Foundation of China [81571807, 51503172]
- China Postdoctoral Science Foundation [2016M602627]
Bead-on-string electrospun fibers containing camptothecin (CPT) are fabricated on the surface of knitted silk fibroin (SF) meshes. Microscopic characterization reveals that the bead-on-string structure is prepared successfully and CPT is mainly located within the beaded structure. Interestingly, the CPT-loaded beaded SF mesh (CPT-SF mesh) has excellent mechanical properties. More importantly, it is able to perform a sustained CPT release without burst release. In vitro cytotoxicity tests further indicate that the CPT-SF mesh shows much stronger anticolon cancer activity in comparison with SF meshes and beaded SF meshes. Hence, the CPT-SF mesh has great potential as a promising local drug delivery system for colon cancer treatment.
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