期刊
LWT-FOOD SCIENCE AND TECHNOLOGY
卷 92, 期 -, 页码 92-100出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.lwt.2018.02.023
关键词
Curcumin; Nanoemulsion; Black pepper; Tween; Antioxidant activity
资金
- Ferdowsi University of Mashhad
- Mashhad University of Medical Sciences [38597]
Curcumin is an important biologically active polyphenolic compound that has been found to contain the ability of a wide range of beneficial biological activities. The aim of this study was to develop a method for the preparation of curcumin nanoparticles (Nano-CUR) with a view to improve its aqueous-phase solubility and examine the effect on its biological properties. Nano-CUR were prepared in black pepper oil (BP oil) as an oil phase and Tween 80 as the surfactant. Nano-CUR was prepared by a modified microemulsion technique and was found to have a narrow particle size distribution in the ranges of 8-26 nm. Nano-CUR was obtained with a spherical shape and mean particle size of 15.7 +/- 3.55 nm when the following optimal conditions were adopted as water/oil (5:1) and oil/surfactant (1:9). Unlike curcumin (bulk), Nano-CUR is readily dispersed in aqueous media. The FIR spectrum indices can be used in order to differentiate nano and non-nano emulsion solutions. Antioxidant activity tests were applied to the Emulsion components, Nano-CUR, and also to Tween 80 + BP oil. Results demonstrated that Nano-CUR has maximum antioxidant activity. In vitro cytotoxicity effect of Nano-CUR was also investigated, which was detected in the treated Neuro2A cells to be up to 15.6 mu g/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据