期刊
LUPUS
卷 27, 期 7, 页码 1202-1206出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203318762598
关键词
SLE; anti-IL-17 antibody; secukinumab; lupus nephritis; psoriasis vulgaris
类别
It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated. After starting secukinumab the clinical and biological features were improved.
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