4.7 Article

Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A(H5N1) Viruses, China

期刊

EMERGING INFECTIOUS DISEASES
卷 19, 期 12, 页码 2021-2024

出版社

CENTERS DISEASE CONTROL
DOI: 10.3201/eid1912.130340

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资金

  1. Major State Basic Research Development Program of China (973 Program) [2011CB505003]
  2. Jiangsu Provincial Natural Science Foundation of China [BK20130442]
  3. earmarked fund for Modern Agro-industry Technology Research System [nycytx-41-G07]
  4. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

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We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009-2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry.

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