期刊
LIFE SCIENCES
卷 198, 期 -, 页码 99-111出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2018.02.033
关键词
Axl inhibitors; Receptor tyrosine kinase; Cancer; Targeted therapy; Small chemicals
资金
- National Natural Science Foundation of China [81502276]
- Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province [A2017013]
- Natural Science Foundation of Hunan Province [2016JJ4077]
- Natural Science Foundation of Guangxi [2015GXNSFEA139003]
Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Therefore, the research on Axl is promising and it is worthy of further investigations. In this review, we present an update on the Axl inhibitors and provide new insights into their latent application.
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