期刊
LARYNGOSCOPE
卷 128, 期 11, 页码 E371-E376出版社
WILEY
DOI: 10.1002/lary.27256
关键词
Vitamin D; head and neck cancer; recurrence; survival
资金
- NATIONAL CANCER INSTITUTE [P50CA097248] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES017885] Funding Source: NIH RePORTER
- NCI NIH HHS [P50 CA097248] Funding Source: Medline
- NIEHS NIH HHS [P30 ES017885] Funding Source: Medline
Objectives/Hypothesis Study Design With an unacceptably low 5-year survival rate and few identified modifiable factors that affect head and neck cancer (HNC) outcomes, HNC survival remains an important public health problem. Vitamin D has been shown to be associated with immune reactivity and improved outcomes for some cancer sites, but findings are mixed, and few studies have examined vitamin D in relation to HNC. This study aimed to assess the association between vitamin D intake and survival outcomes in HNC patients. Prospective cohort study. Methods Results This study utilized data on 434 HNC patients with valid pretreatment food frequency questionnaire data who participated in the University of Michigan Head and Neck Specialized Program of Research Excellence epidemiology project. Cox proportional hazard models were used to estimate the associations between total, dietary, and supplemental vitamin D intake and HNC outcomes, while adjusting for other known prognostic factors. After multivariable adjustment, we found a statistically significant inverse trend between total vitamin D intake and recurrence (Q4 vs. Q1 hazard ratio: 0.47, 95% confidence interval: 0.20-1.10, P trend = .048). We observed no association with dietary or supplemental intake separately, and no association was observed with all-cause or HNC-specific mortality. Conclusions Level of Evidence These findings suggest that HNC patients with lower levels of vitamin D intake are at higher risk of recurrence. If borne out in future studies, our results suggest that increased vitamin D intake through dietary intervention or the use of supplements may be a feasible intervention for prevention of recurrence in HNC patients. 2b. Laryngoscope, E371-E376, 2018
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