期刊
LABORATORY MEDICINE
卷 49, 期 2, 页码 154-159出版社
OXFORD UNIV PRESS
DOI: 10.1093/labmed/lmx068
关键词
alpha-thalassemia; deletional HbH; nondeletional HbH; hematological parameters; Hb Constant Spring
Objectives: To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods: Samples of 43 deletional HbH diseases, which included 39-(SEA)/-alpha(3.7) 4-(SE)(A)/-alpha(4.2) and 22 nondeletional HbH diseases (-(SEA)/alpha(cs)alpha), Were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed. Results: The deletional HbH disease had higher levels of RBC counts, total Hb, pack cell volume (PCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), HbA, and HbA(2) than did the nondeletional HbH disease. A negative correlation between HbH and RBC counts was detected in the group of deletional HbH disease, while a positive correlation between HbH and RBC counts, total Hb, and PCV was found in the group of nondeletional HbH disease. These results reflected that samples with nondeletional HbH showed more anemic features than those with the deletional HbH.
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