期刊
JOURNAL OF VETERINARY INTERNAL MEDICINE
卷 32, 期 3, 页码 999-1008出版社
WILEY
DOI: 10.1111/jvim.15123
关键词
biomarkers; diarrhea and vomiting; dogs; inflammation
资金
- Veterinary Clinical Sciences Incentive Grant, Iowa State University, College of Veterinary Medicine [290-05-30 00-0001]
BackgroundLittle information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD). ObjectivesEvaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment. AnimalsSixteen dogs with idioptahic IBD and 13 healthy dogs. MethodsProspective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment. ResultsSerum CRP (median 3.5 mg/L; range: 0.1-52.4 mg/L), fecal cCP (median 92.3 g/g; range: 0.03-637.5 g/g), and CIBDAI scores significantly increased in dogs with IBD before treatment compared with serum CRP (median 0.2 mg/L; range: 0.1-11.8 mg/L; P<.001), fecal cCP (median 0.67 g/g; range: 0.03-27.9 g/g; P<.001) and CIBDAI (P<.001) after treatment. No significant associations between CIBDAI scores and before or after treatment serum biomarkers. There was a significant association between fecal cCP and CIBDAI scores before treatment (rho=0.60, P=.01). CRP and fecal cCP significantly decreased after treatment (median 3.5 mg/L v. 0.2 mg/L; P<.001 and 92.3 g/g v. 0.67 g/g; P = .001, respectively). Conclusions and Clinical ImportanceOur data indicate that measurement of fecal cCP concentration is a useful biomarker for noninvasive evaluation of intestinal inflammation. Dogs with severe signs of GI disease more often have abnormal markers than dogs having less severe disease.
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