期刊
ACTA VIROLOGICA
卷 57, 期 1, 页码 85-86出版社
AEPRESS SRO
DOI: 10.4149/av_2013_01_85
关键词
Commelina communis L.; influenza A virus; alkaloids; homonojirimycin
类别
资金
- National Natural Science Foundation of China [81102870]
- Foundation of He 'nan Educational Committee [128360014]
We have previously examined the antiviral effects of total alkaloids from Commelina communis L. (TAC). Here we investigated the active constituents of TAC, responsible for the antiviral effect. Harman, homonojirimycin (HNJ) and 2,5-dihydroxymethy1-3,4-dihydroxypyrrolidine were isolated from TAC by HPLC. Only HNJ showed strong antiviral activity against influenza A/PR/8/34 virus (H1N1) as measured by cytopathic effect reduction assay. The results suggest that HNJ is one of the active components of TAC.
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