期刊
JOURNAL OF UROLOGY
卷 199, 期 6, 页码 1427-1433出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.juro.2017.11.112
关键词
kidney neoplasms; carcinoma; renal cell; lymph nodes; sentinel lymph nodes; tomography; emission-computed; single-photon
资金
- European Urological Scholarship Programme research fellowship at Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute
Purpose: Lymphatic drainage from renal tumors is unpredictable. In vivo drainage studies of primary lymphatic landing sites may reveal the variability and dynamics of lymphatic connections. The purpose of this study was to investigate the lymphatic drainage pattern of renal tumors in vivo with single photon emission/computerized tomography after intratumor radiotracer injection. Materials and Methods: We performed a phase II, prospective, single arm study to investigate the distribution of sentinel nodes from renal tumors on single photon emission/computerized tomography. Patients with cT1-3 (less than 10 cm) cN0M0 renal tumors of any subtype were enrolled in analysis. After intratumor ultrasound guided injection of 0.4 ml Tc-99m-nanocolloid we performed preoperative imaging of sentinel nodes with lymphoscintigraphy and single photon emission/computerized tomography. Sentinel and locoregional non sentinel nodes were resected with a gamma probe combined with a mobile gamma camera. The primary study end point was the location of sentinel nodes outside the locoregional retroperitoneal templates on single photon emission/computerized tomography. Using a Simon minimax 2-stage design to detect a 25% extra-locoregional retroperitoneal template location of sentinel nodes on imaging at alpha = 0.05 and 80% power at least 40 patients with sentinel node imaging on single photon emission/computerized tomography were needed. Results: Of the 68 patients 40 underwent preoperative single photon emission/computerized tomography of sentinel nodes and were included in primary end point analysis. Lymphatic drainage outside the locoregional retroperitoneal templates was observed in 14 patients (35%). Eight patients (20%) had supra diaphragmatic sentinel nodes. Conclusions: Sentinel nodes from renal tumors were mainly located in the respective locoregional retroperitoneal templates. Simultaneous sentinel nodes were located outside the suggested lymph node dissection templates, including supradiaphragmatic sentinel nodes in more than a third of the patients.
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