期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 16, 期 9, 页码 1830-1842出版社
WILEY
DOI: 10.1111/jth.14227
关键词
epidemiology; hemorrhage; idiopathic thrombocytopenic purpura; platelet count; risk factors
资金
- Delegation Regionale a la Recherche Clinique des Hopitaux de Toulouse 2012
- French National Society of Internal Medicine (Societe Nationale Francaise de Medecine Interne)
- French referral center for autoimmune cytopenias
- French National Network for Rare Diseases in Immunohematology (MaRIH)
- CSL Behring
- Novartis
Background The aim of this cross-sectional study was to assess risk factors for bleeding in immune thrombocytopenia (ITP) adults, including the determination of platelet count thresholds. Methods We selected all newly diagnosed ITP adults included in the Cytopenies Auto-immunes Registre Midi-PyreneEN (CARMEN) register and at the French referral center for autoimmune cytopenias. The frequencies of any bleeding, mucosal bleeding and severe bleeding (gastrointestinal, intracranial, or macroscopic hematuria) at ITP onset were assessed. Platelet count thresholds were assessed by the use of receiver operating characteristic curves. All potential risk factors were included in logistic regression models. Results Among the 302 patients, the frequencies of any, mucosal and severe bleeding were 57.9%, 30.1%, and 6.6%, respectively. The best discriminant threshold of platelet count for any bleeding was 20 x 10(9) L-1. In multivariate analysis, factors associated with any bleeding were platelet count (< 10 x 10(9) L-1 versus 20 x 10(9) L-1, odds ratio [OR] 48.2, 95% confidence interval [CI] 20.0-116.3; between 10 x 10(9) L-1 and 19 x 10(9) L-1 versus 20 x 10(9) L-1, OR 5.2, 95% CI 2.3-11.6), female sex (OR 2.6, 95% CI 1.3-5.0), and exposure to non-steroidal anti-inflammatory drugs (NSAIDs) (OR 4.8, 95% CI 1.1-20.7). A low platelet count was also the main risk factor for mucosal bleeding. Exposure to anticoagulant drugs was associated with severe bleeding (OR 4.3, 95% CI 1.3-14.1). Conclusions Platelet counts of < 20 x 10(9) L-1 and < 10 x 10(9) L-1 were thresholds for major increased risks of any and mucosal bleeding. Platelet count, female sex and exposure to NSAIDs should be considered for assessment of the risk of any bleeding. Exposure to anticoagulant drugs was a major risk factor for severe bleeding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据