Methyldopa electrochemical sensor based on a glassy carbon electrode modified with Cu/TiO2 nanocomposite

A Cu/TiO2 nanocomposite modified glassy carbon electrode (Cu//TiO2/GCE) was fabricated to detect methyldopa by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods. Compared with bare GCE, the Cu/TiO2/GCE exhibited excellent electrochemical activity for the oxidation of methyldopa. Using DPV technique, the calibration curves for methyldopa were found linear in the concentration range of 0.5-800.0 mu M and the detection limit (S/N = 3) was calculated to be 0.23 mu M. Additionally, the prepared electrochemical sensor of Cu/TiO2/GCE demonstrated a practical feasibility in methyldopa tablets and in urine samples analysis.