期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 15, 期 141, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2017.0916
关键词
NADH:ubiquinone oxidoreductase; PCET; proton transfer; molecular simulations; bioenergetics
资金
- European Research Council (ERC) under the European Union's Horizon research and innovation programme [715311]
Biological energy conversion is driven by efficient enzymes that capture, store and transfer protons and electrons across large distances. Recent advances in structural biology have provided atomic-scale blueprints of these types of remarkable molecular machinery, which together with biochemical, biophysical and computational experiments allow us to derive detailed energy transduction mechanisms for the first time. Here, I present one of the most intricate and least understood types of biological energy conversion machinery, the respiratory complex I, and how its redox-driven proton-pump catalyses charge transfer across approximately 300 angstrom distances. After discussing the functional elements of complex I, a putative mechanistic model for its action-at-a-distance effect is presented, and functional parallels are drawn to other redox- and light-driven ion pumps.
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