期刊
HEADACHE
卷 55, 期 9, 页码 1209-1217出版社
WILEY
DOI: 10.1111/head.12617
关键词
migraine; genetics; genetic polymorphism; nitric oxide; nitric oxide synthase genes; risk factor
资金
- Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Madrid, Spain [PI12/00241, PI12/00324, RETICS RD12/0013/0002]
- Junta de Extremadura, Merida, Spain [GR10068]
- FEDER
Background/ObjectivesMany biochemical, pharmacological, neuropathological, and experimental data suggest a possible role of nitric oxide in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the neuronal nitric oxide synthase gene (NOS1 or nNOS; chromosome 12q24.22) and the risk for migraine. MethodsWe studied the frequency of the of rs7977109 and rs693534 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay. As a secondary analysis, we studied the possible influence of gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura on the genotypes frequency. ResultsThe frequencies of rs7977109 and rs693534 genotypes and allelic variants were not associated with the risk for migraine with OR for minor alleles=0.94 (95% CI 0.72-1.23) and=0.88 (0.68-1.15), respectively, and the lack of association was not influenced by gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura. ConclusionNOS1 rs7977109 and rs693534 genotypes and allelic variants are not associated with the risk for migraine in Caucasian Spanish people.
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