期刊
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
卷 118, 期 1, 页码 2-6出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jfma.2018.04.013
关键词
MicroRNA-17-92 cluster; Proliferation; Immune regulation
资金
- Chang Gung Memorial Hospital [CORPG3F0131-2]
- Ministry of Science and Technology in Taiwan [NMRPD1F1121-2]
MicroRNAs (MiR, MiRNA) are small single-stranded non-coding RNAs that play an important role in the regulation of gene expression. MircoRNAs exert their effect by binding to complementary nucle-otide sequences of the targeted messenger RNA, thus forming an RNA-induced silencing complex. The mircoRNA-17-92 cluster encoded by the miR-17-92 host gene is first found in malignant B-cell lymphoma. Recent research identifies the miR-17-92 cluster as a crucial player in the development of the immune system, the heart, the lung, and oncogenic events. In light of the miR-17-92 cluster's increasing role in regulating the immune system, our review will discuss the latest knowledge regarding its involvement in cells of both innate and adaptive immunity, including B cells, subsets of T cells such as Th1, Th2, T follicular helper cells, regulatory T cells, monocytes/macrophages, NK cells, and dendritic cells, and the possible targets that are regulated by its members. Copyright (C) 2018, Formosan Medical Association. Published by Elsevier Taiwan LLC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据