期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 29, 期 10, 页码 2026-2033出版社
SOC BRASILEIRA QUIMICA
DOI: 10.21577/0103-5053.20180077
关键词
surface chemistry; Ag+ ion; LSPR spectroscopy
资金
- FAPEMIG [CEX-APQ-02392/15, CEX-RED-00010-14]
- CNPq [407279/2013-0]
- CAPES
The investigations of the antibacterial actions, observed in ternary associations involving silver nanoparticles (AgNPs), chitosan and the antibiotics azithromycin (AZ), levofloxacin (LE) or tetracycline (TE), against Gram-negative and Gram-positive bacterial strains, were performed by in vitro antimicrobial susceptibility testing and checkerboard assays. The pH impact in the culture medium was carefully discarded, but preserving the best conditions for solubilizing chitosan. The synergistic antibacterial effects were observed in the most combinations of AgNPs, chitosan and antibiotic, leading to a reduction from 37 to 97% in the minimum inhibitory concentration of the drugs. The mechanisms for the enhanced antimicrobial effects were proposed based on the investigations of the adsorptions of the drugs on the silver surfaces through surface-enhanced Raman scattering (SERS) spectroscopy.
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