期刊
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
卷 19, 期 3, 页码 248-U194出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jamda.2017.09.012
关键词
Anxiety; cognitive decline; accidental falls
资金
- Irish Government
- Atlantic Philanthropies
- Irish Life PLC
- Global Brain Health Institute fellowship
Background: Fear of falling (FoF) is present in 20% to 85% of older adults and may be an early marker of decline in global cognitive functioning (GCF). We tested the hypothesis that FoF is associated with lower levels of GCF (cross-sectional) and greater decline in GCF (prospective) in adults aged 50 and older. Design: Observational cohort study. Setting: The Irish Longitudinal Study on Ageing, a population-based study. Participants: Data were from 4931 participants (mean age 62.9 +/- 9.1, range 50-98, 54.3% female). Measurements: FoF was based on self-report in 2010. GCF was measured with the Montreal Cognitive Assessment (MoCA) and Mini Mental Status Examination (MMSE) in 2010 and 2014. The cross-sectional association was examined using linear regression unadjusted and after adjustment for demographic and health factors. The prospective association between FoF and the odds of > 1-SD decline in GCF were examined using logistic regression. Interaction with age and mediation by social and physical activities were examined. Results: In 2010, 21.9% of participants reported FoF. In the unadjusted cross-sectional models, those with FoF had lower scores on the MoCA (B - 1.15, 95% confidence interval [CI] - 1.40 to - 0.90) and MMSE (B - 0.52,CI - 0.67 to - 0.37). In the unadjusted prospective models, FoF was associated with a greater odds of decline in MoCA (odds ratio [OR] 1.60, CI 1.26-2.04) and MMSE (OR 1.64, CI 1.29-2.08). After adjustment for covariates, all associations attenuated and were no longer statistically significant, except the association with decline in MoCA (OR 1.32, CI 1.01-1.71). No statistically significant interaction with age was found (P >. 37). Additional adjustment for social and physical activity did not change the results. Conclusions: The findings provide weak evidence for FoF as a predictor of cognitive decline. (C) 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
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