期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 71, 期 10, 页码 1149-1166出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2018.01.017
关键词
heart failure; restrictive cardiomyopathy; sarcoidosis
资金
- National Institute on Aging [R21AG53512]
- Alnylam
- Pfizer
- Prothena
Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, particularly primary and secondary forms of iron overload, as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies. 66) (c) 2018 by the American College of Cardiology Foundation.
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