期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 72, 期 1, 页码 2-11出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2018.04.048
关键词
diastolic dysfunction; echocardiography; pre-eclampsia; pulmonary edema; right ventricular systolic pressure; speckle tracking echocardiography
BACKGROUND Pre-eclampsia with severe features (PEC) is a pregnancy-specific syndrome characterized by severe hypertension and end-organ dysfunction, and is associated with short-term adverse cardiovascular events, including heart failure, pulmonary edema, and stroke. OBJECTIVES The authors aimed to characterize the short-term echocardiographic, clinical, and laboratory changes in women with PEC, focusing on right ventricular (RV) systolic pressure (RVSP) and echocardiographic-derived diastolic, systolic, and speckle tracking parameters. METHODS In this prospective observational study, the authors recruited 63 women with PEC and 36 pregnant control patients. RESULTS The PEC cohort had higher RVSP (31.0 +/- 7.9 mm Hg vs. 22.5 +/- 6.1 mm Hg; p < 0.001) and decreased global RV longitudinal systolic strain (RVLSS) (-19.6 +/- 3.2% vs. -23.8 +/- 2.9% [p < 0.0001]) when compared with the control cohort. For left-sided cardiac parameters, there were differences (p < 0.001) in mitral septal e' velocity (9.6 +/- 2.4 cm/s vs. 11.6 +/- 1.9 cm/s), septal E/e' ratio (10.8 +/- 2.8 vs. 7.4 +/- 1.6), left atrial area size (20.1 +/- 3.8 cm(2) vs. 17.3 +/- 2.9 cm(2)), and posterior and septal wall thickness (median [interquartile range]: 1.0 cm [0.9 to 1.1 cm] vs. 0.8 cm [0.7 to 0.9 cm], and 1.0 cm [0.8 to 1.2 cm] vs. 0.8 cm [0.7 to 0.9 cm]). Eight women (12.7%) with PEC had grade II diastolic dysfunction, and 6 women (9.5%) had peripartum pulmonary edema. CONCLUSIONS Women with PEC have higher RVSP, higher rates of abnormal diastolic function, decreased global RVLSS, increased left-sided chamber remodeling, and higher rates of peripartum pulmonary edema, when compared with healthy pregnant women. (C) 2018 by the American College of Cardiology Foundation.
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