期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 1, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/mco.29906
关键词
cell death; apoptosis; bcl-2; therapy; cancer; noxa
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [KFO 286-RP3, SFB 832-A9]
- Koln Fortune Program/Faculty of Medicine, University of Cologne
Biochemical analyses have characterized the BH3-only protein family member Noxa as a sensitizer with weak proapoptotic activity. Investigations into cancer cell responses to chemotherapeutic agents have identified Noxa as a pivotal factor mediating the cytotoxic effect of a plethora of anticancer treatments independent of its own pro-apoptotic activity. Accumulating evidence now suggests that tumor cells exert a number of strategies to counteract Noxa function by exploiting diverse cellular regulatory circuits that normally govern Noxa expression during cellular stress responses. Here, we summarize data concerning the role of Noxa in cancer chemosensitivity and highlight the potential of this enigmatic BH3-only protein family member in current and novel anticancer therapies.
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