期刊
ENVIRONMENTAL HEALTH INSIGHTS
卷 8, 期 -, 页码 11-20出版社
SAGE PUBLICATIONS LTD
DOI: 10.4137/EHI.S15260
关键词
welding fume; pulmonary toxicity; chromium; nickel; copper; particulate matter
资金
- National Occupational Research Agenda (NORA) of the National Institute for Occupational Safety and Health (NIOSH)
Epidemiology has indicated a possible increase in lung cancer among stainless steel welders. Chromium (Cr) is a primary component of stainless steel welding fume. There is an initiative to develop alternative welding consumables [ nickel (Ni)-and copper (Cu)-based alloys] that do not contain Cr. No study has been performed to evaluate the toxicity of fumes generated from Ni-and Cu-based consumables. Dose-response and time-course effects on lung toxicity of a Ni-and Cu-based welding fume (Ni-Cu WF) were examined using an in vivo and in vitro bioassay, and compared with two other well-characterized welding fumes. Even though only trace amounts of Cr were present, a persistent increase in lung injury and inflammation was observed for the Ni-Cu WF compared to the other fumes. The difference in response appears to be due to a direct cytotoxic effect by the Ni-Cu WF sample on lung macrophages as opposed to an elevated production of reactive oxygen species (ROS).
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