期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 20, 页码 6203-6207出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b02761
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资金
- Japan Society for the Promotion of Science [26288053, 17KT0011, 17H03060]
- Uehara Memorial Foundation
- Naito Foundation
- Inoue Foundation of Science
Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp(3))-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp(3))-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp(3))-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp(3))-H bond functionalization by an achiral catalyst (Yb(OTf)(3), second [1,5]-hydride shift).
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