期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 5, 页码 1627-1631出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b00643
关键词
-
资金
- National Institutes of Health [GM058160, GM122483, GM058160-17S1]
- MIT
- Bristol Myers Squibb
- Samsung Group
- MIT through the Undergraduate Research Opportunities Program
Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据