期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 26, 页码 8091-8095出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b04592
关键词
-
资金
- Cancer Prevention Research Institute of Texas (CPRIT)
- Welch Foundation [C-1819]
- AbbVie Stemcentrx
- Rice University
Namenamicin is a rare natural product possessing potent cytotoxic properties that may prove useful as a lead compound for payloads of antibody-drug conjugates (ADCs). Its scarcity, coupled with the uncertainty of its full absolute configuration, elevates it to an attractive synthetic target. Herein we describe the total synthesis of the two C7'-epimers of namenamicin and assign its complete structure, opening the way for further chemical and biological studies toward the discovery of potent payloads for ADCs directed toward targeted cancer therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据