期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 6, 页码 2355-2362出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b12447
关键词
-
资金
- University of Strasbourg
- European Research Council, ERC Advanced Grant [2009-247365]
- DFG Emmy Noether program [BI 1805/2-1]
- European Research Council [616907]
- European Research Council (ERC) [616907] Funding Source: European Research Council (ERC)
Virus-like particles (VLPs) have been created from luminescent Pt(II) complex amphiphiles, able to form supramolecular structures in water solutions, that can be encapsulated or act as templates of cowpea chlorotic mottle virus capsid proteins. By virtue of a bottom-up molecular design, icosahedral and nonicosahedral (rod-like) VLPs have been constructed through diverse pathways, and a relationship between the molecular structure of the complexes and the shape and size of the VLPs has been observed. A deep insight into the mechanism for the templated formation of the differently shaped VLPs was achieved, by electron microscopy measurements (TEM and STEM) and bulk analysis (FPLC, DLS, photophysical investigations). Interestingly, the obtained VLPs can be visualized by their intense emission at room temperature, generated by the self-assembly of the Pt(II) complexes. The encapsulation of the luminescent species is further verified by their higher emission quantum yields inside the VLPs, which is due to the confinement effect of the protein cage. These hybrid materials demonstrate the potential of tailor-made supramolecular systems able to control the assembly of biological building blocks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据