期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 24, 页码 7462-7465出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b04891
关键词
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资金
- NIH [GM-118176]
- LEO Pharmaceuticals
- Vividion Therapeutics
- Nankai University
- Bayer Science and Education Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM118176] Funding Source: NIH RePORTER
A divergent strategy for assembling pyrone diterpenes is presented. Capitalizing on the unique stereo-and chemoselectivity features of radical-based chemistry, the core decalin of these structures is efficiently forged using an electrochemically assisted oxidative radical polycyclization while key peripheral substituents are appended using decarboxylative radical cross couplings. In this way, access to four natural products (subglutinols A/B, higginsianin A, and sesquicillin A) is achieved in a concise and stereocontrolled fashion that is modular and amenable to future medicinal chemistry explorations.
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