期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 8, 页码 2743-2747出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b13087
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资金
- Royal Society
- K. C. Wong Fellowship
- EPSRC [EP/L015366/1]
- European Research Council (ERC) [639594 CatHet]
- Engineering and Physical Sciences Research Council [EP/K03927X/1] Funding Source: researchfish
- BBSRC [BB/F011539/1] Funding Source: UKRI
- EPSRC [EP/L011999/1, EP/K03927X/1] Funding Source: UKRI
A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C-C bond activation of aminocyclopropanes provides rhodacyclopentanones. These intermediates are effective for intramolecular C-H metalation of either an N-aryl or N-vinyl unit en route to azepine ring systems. Thus, byproduct-free heterocyclizations are enabled by sequential C-C activation and C-H functionalization steps.
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