期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 4, 页码 1385-1393出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b10694
关键词
-
资金
- National Key Basic Research Program of the PRC [2014CB744504, 2014CB744501]
- Natural Science Foundation of Jiangsu Province [BK20160017, BK20130863]
- National Natural Science Foundation of China [81530054, 21603106]
- RMIT
Mesoporous solids have been widely used in various biomedical areas such as drug delivery and tumor therapy. Although deformability has been recognized as a prime important characteristic influencing cellular uptake, the synthesis of deformable mesoporous solids is still a great challenge. Herein, deformable thioether-, benzene-, and ethane-bridged hollow periodic mesoporous organosilica (HPMO) nanocapsules have successfully been synthesized for the first time by a preferential etching approach. The prepared HPMO nanocapsules possess uniform diameters (240-310 nm), high surface areas (up to 878 m(2).g(-1)), well-defined mesopores (2.6-3.2 nm), and large pore volumes (0.33-0.75 m(3).g(-1)). Most importantly, the HPMO nanocapsules simultaneously have large hollow cavities (164-270 nm), thin shell thicknesses (20-38 nm), and abundant organic moiety in the shells, which endow a lower Young's modulus (E-Y) of 3.95 MPa than that of solid PMO nanoparticles (251 MPa). The HPMOs with low E-Y are intrinsically flexible and deformable in the solution, which has been well-characterized by liquid cell electron microscopy. More interestingly, it is found that the deformable HPMOs can easily enter into human breast cancer MCF-7 cells via a spherical-to-oval morphology change, resulting in a 26-fold enhancement in cellular uptake (43.1% cells internalized with nanocapsules versus 1.65% cells with solid counterparts). The deformable HPMO nanocapsules were further loaded with anticancer drug doxorubicin (DOX), which shows high killing effects for MCF-7 cells, demonstrating the promise for biomedical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据