期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 20, 页码 6212-6216出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b03063
关键词
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资金
- NCI [R01 CA126827]
- American Cancer Society [09-016-01 CDD]
- NIGMS [T32GM105538]
An enantioselective cross-dehydrogenative coupling (CDC) reaction to access tetrahydropyrans has been developed. This process combines in situ Lewis acid activation of a nucleophile in concert with the oxidative formation of a transient oxocarbenium electrophile, leading to a productive and highly enantioselective CDC. These advances represent one of the first successful applications of CDC for the enantioselective couplings of unfunctionalized ethers. This system provides efficient access to valuable tetrahydropyran motifs found in many natural products and bioactive small molecules.
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