期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 22, 页码 6904-6911出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b02350
关键词
-
资金
- Innovation and Technology Commission [ITC-CNERC14SC01]
- National Science Foundation of China [21788102]
- National Basic Research Program of China (973 Program) [2013CB834701, 2013CB834702]
- Research Grants Council of Hong Kong [16301614, 16305015, N_HKUST604/14, A-HKUST605/16]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482]
Multimodality imaging is highly desirable for accurate diagnosis by achieving high sensitivity, spatial temporal resolution, and penetration depth with a single structural unit. However, it is still challenging to integrate fluorescent and plasmonic modalities into a single structure, as they are naturally incompatible because of significant fluorescence quenching by plasmonic noble-metal nanoparticles. Herein, we report a new type of silver@AIEgen (aggregation-induced emission luminogen) core-shell nanoparticle (AACSN) with both strong aggregated-state fluorescence of the AlEgen and distinctive plasmonic scattering of silver nanoparticles for multimodality imaging in living cells and small animals. The AACSNs were prepared through a redox reaction between silver ions and a redoxactive AlEgen, which promoted synergistic formation of the silver core and self-assembly of the AlEgen around the core. The resulting AACSNs exhibited good biocompatibility and high resistance to environmental damage. As a result, excellent performance in fluorescence imaging, dark-field microscopy, and X-ray computed tomography-based multimodality imaging was achieved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据