期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 13, 页码 4489-4493出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b01181
关键词
-
资金
- Swiss National Science Foundation [155967, 175507]
Annulated pyridones are an important scaffold found in many biologically active compounds. A Ni(0)-catalyzed C-H functionalization of 2- and 4-pyridones is disclosed, providing access to annulated pyridones via enantioselective intramolecular olefin hydroarylation. Key to the success of the transformation was the development of a sterically hindered and tunable N-heterocyclic carbene ligand resembling a chiral version of IPr. This ligand allows for mild reaction temperatures, and leads to the annulated pyridones in excellent yields and enantioselectivities.
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