期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
卷 4, 期 3, 页码 385-394出版社
KARGER
DOI: 10.1159/000366119
关键词
Biomarkers; Cerebrospinal fluid; Matrix metalloproteinases; Myelin basic protein; Neurofilament; Ventricular dilation; White matter disease
资金
- Swedish Brain Power
- Swedish Research Council
- Alzheimer's Association
- cNEUPRO
- Wolfson Foundation
- Sahlgrenska University Hospital
- Inga-Britt and Arne Lundberg Research Foundation
- Gothenburg Medical Society
- Swedish Medical Society
- Demensfonden
- Stiftelsen Gamla Tjanarinnor
- Gun och Bertil Stohnes stiftelse
- Adlerbert Research Foundation
- Alzheimer Foundation, Sweden
Background: Small vessel disease (SVD) represents a common often progressive condition in elderly people contributing to cognitive disability. The relationship between cerebrospinal fluid (CSF) biomarkers and imaging correlates of SVD was investigated, and the findings were hypothesized to be associated with a neuropsychological profile of SVD. Methods: CSF SVDrelated biomarkers [neurofilament light (NF-L), myelin basic protein (MBP), soluble amyloid precursor protein-beta (sAPP beta), matrix metalloproteinases (MMPs), and tissue inhibitor of metalloproteinase (TIMP)] were analysed in 46 non-demented elderly with imaging findings of SVD. We assessed the relationship between the CSF biomarkers and white matter hyperintensity (WMH) volume, diffusion-weighted imaging and atrophy as well as their association with neuropsychological profiles. Results: The WMH volume correlated with ventricular dilation, which was associated with executive function and speed and attention. Increased WMH and ventricular dilation were related to increased CSF levels of TIMP-1, NF-L and MBP and to decreased sAPP beta. A positive correlation was found between the CSF biomarker MMP-9 and WMH progression. Conclusions: The link between progressive WMH and MMP-9 suggests an involvement of the enzyme in white matter degeneration. CSF TIMP-1, NF-L, MBP and sAPP beta may function as biological markers of white matter damage. (C) 2014 S. Karger AG, Basel
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