期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 30, 页码 9332-9336出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b03619
关键词
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资金
- National Natural Science Foundation of China [21602104]
- Natural Science Foundation of Jiangsu Province, China [BK 20160986]
- Nanjing Tech University [3983500176]
- Singapore Ministry of Education [MOE2015-T1-001-070 (RG5/15), MOE2014-T1- 001-102 (RG9/14)]
- Jiangsu National Synergetic Innovation Center for Advanced Materials
A general Pd-catalyzed intermolecular reductive Heck reaction of both terminal and internal unactivated aliphatic alkenes has been first developed. This method affords gamma- and delta-arylated alkyl carboxylic acid derivatives in high yields with complete anti-Markovnikov selectivity. Notably, the coupling process is stereoretentive for the alkyl chain. Mechanistically, alkyl palladacycle intermediates stabilized by directing group and ligand, hydride species multigenerated from PS/TFA reductant, are two key factors that successfully promote the reaction and regioselectivity.
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