期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 79, 期 2, 页码 345-352出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2018.02.040
关键词
anti-inflammatory therapy; cardiovascular disease; comorbidities; IL-17; interleukin 17; psoriasis; systemic inflammation
类别
资金
- Novartis Pharmaceuticals Corporation
In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoriasis is evidenced by the higher burden of comorbidities and shorter life expectancies of patients with psoriasis, particularly those with early-onset and severe disease. Notably, psoriasis is associated with an increased risk for cardiovascular disease, which is the most common cause of morbidity and mortality in patients with psoriasis. In this review, we examine the association between psoriasis and cardiovascular disease and specifically focus on the role of interleukin 17-mediated inflammation as a potential mechanistic link between psoriasis and cardiovascular disease. Moreover, we describe potential treatment approaches to reduce the burden of cardiovascular disease in patients with psoriasis and discuss the clinical importance of the association of these 2 diseases with respect to patient management and education.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据