期刊
CLINICAL AND TRANSLATIONAL MEDICINE
卷 3, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1186/s40169-014-0041-2
关键词
Macrophage reprogramming; Cancer; Biomaterials; Anti-angiogenic therapy; Recruitment inhibition; Tissue engineering; Foreign body response
资金
- National Science Foundation [CBET 1227867]
- Roy J. Carver Charitable Trust [13-4265]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1227867] Funding Source: National Science Foundation
Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macrophage phenotypes with varied effector functions, molecular determinants, cytokine and chemokine profiles, as well as receptor expression. In tumor microenvironments, the subset of macrophages known as tumor-associated macrophages generates byproducts that enhance tumor growth and angiogenesis, making them attractive targets for anti-cancer therapeutics. With respect to wound healing and the foreign body response, there is a necessity for balance between pro-inflammatory, wound healing, and regulatory macrophages in order to achieve successful implantation of a scaffold for tissue engineering. In this review, we discuss the multitude of ways macrophages are known to be important in cancer therapies and implanted biomaterials.
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