期刊
GUT MICROBES
卷 5, 期 3, 页码 419-429出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.29417
关键词
functional gastrointestinal disorders; IBS; gut-brain axis; microbiota; anxiety; depression
资金
- CIHR
- Nestle
- HHS Research Early Career Award
- CIHR-CAG Postdoctoral Fellowship
Functional gastrointestinal disorders (FGIDs) are highly prevalent and pose a significant burden on health care and society, and impact patients' quality of life. FGIDs comprise a heterogeneous group of disorders, with unclear underlying pathophysiology. They are considered to result from the interaction of altered gut physiology and psychological factors via the gut-brain axis, where brain and gut symptoms are reciprocally influencing each other's expression. Intestinal microbiota, as a part of the gut-brain axis, plays a central role in FGIDs. Patients with Irritable Bowel Syndrome, a prototype of FGIDs, display altered composition of the gut microbiota compared with healthy controls and benefit, at the gastrointestinal and psychological levels, from the use of probiotics and antibiotics. This review aims to recapitulate the available literature on FGIDs and microbiota-gut-brain axis.
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